However, a few risk factors have been identified that are associated with the development of MGUS. The etiology of MGUS is to a large extent unknown. Each year, approximately 1% of patients with MGUS progress to MM. MGUS is the first pathogenic step in the development of multiple myeloma (MM), and patients with MGUS are also at an increased risk of developing other lymphoproliferative conditions. Patients with MGUS are usually asymptomatic therefore, MGUS is often incidentally diagnosed by blood tests ordered for other medical concerns. Monoclonal gammopathy of undetermined significance (MGUS) is a disorder of the plasma cell overproducing monoclonal protein (M protein). Further research is needed to explore the potential mechanisms underlying the development of MGUS and to confirm risk factors, both modifiable and non-modifiable. The sparse existing literature suggests an increased risk of MGUS associated with several risk factors related to immune function. Despite the limited research, a significant elevated risk for being diagnosed with MGUS was associated with several specific prior infections, inflammatory disorders, and smoking. Studies evaluating factors associated with MGUS risk are limited, with conflicting conclusions regarding risk associated with obesity. Five case-control and three cohort studies were eligible for data extraction. Articles were limited to those written in English and published before February 2019. We identified epidemiological studies from PubMed and Scopus. The protocol for this study was registered on the PROSPERO registry for systematic reviews. We systematically reviewed observational epidemiological studies that examined sociodemographic, clinical, and behavioral risk factors for the development of MGUS. Older age, male sex, black race, and family history of MGUS increase the risk of MGUS, yet other risk factors are known. We are all here to help and learn together.Īnd, if you really want to get into music visualization.Monoclonal gammopathy of undetermined significance (MGUS), precursor of multiple myeloma, is an asymptomatic plasma cell disorder that overproduces serum monoclonal protein. Don't be shocked if you post your masterpiece and people have a few useful suggestions for you. As such, we encourage an atmosphere of helpful critique. This community is meant to be a place of helpfulness. If you are here for a critique of your work Screenshots and/or videos of the thing you want to create It includes things such as:Įxact version of AE you use - not just "CS6" or "CC" or even "CC 2019", but the actual version number (for example, 11.0.4 or 12.2.1 or 13.2.0 or 13.7.2 or 13.8.1 or 17.0.2) However, for useful help, please provide as much info as possible. Once you've gone through that, here are some other helpful resources: A foundation in the basics now will prevent much frustration later. If you'd like to join us on Discord, you can do it here! Are you looking for critiques for your piece or are you showing off someone else's work that you've found that is inspirationally excellent? If you post a video, please explain in the title of your post why you're posting it. We are not here to be sold to or spammed, so no posting of your AE templates, please. We're here to help with your After Effects problems, critique your pieces, and sometimes provide a spot of inspiration. Don't downvote a relevant submission you simply don't like kindly explain in a comment how it could be improved - anonymous downvotes don't help anybody.
0 kommentar(er)
